Microbial Persistence and the Road to Drug Resistance
نویسندگان
چکیده
منابع مشابه
Microbial persistence and the road to drug resistance.
Microbial drug persistence is a widespread phenomenon in which a subpopulation of microorganisms is able to survive antimicrobial treatment without acquiring resistance-conferring genetic changes. Microbial persisters can cause recurrent or intractable infections, and, like resistant mutants, they carry an increasing clinical burden. In contrast to heritable drug resistance, however, the biolog...
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A previously reported form of microbial persistence whereby large populations of tubercle bacilli can be made to "vanish" uniformly from the tissues of mice has been shown to occur generally throughout each group of animals subjected to the experimental procedure; it does not reflect the eradication of the bacilli in the majority of animals with their persistence and ultimate revival in only a ...
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ژورنال
عنوان ژورنال: Cell Host & Microbe
سال: 2013
ISSN: 1931-3128
DOI: 10.1016/j.chom.2013.05.009